TRIA Orthopedics First in Minnesota to Test Breakthrough GelrinC™ Implant to Regenerate Knee Cartilage

TRIA Orthopedics First in Minnesota to Test Breakthrough GelrinC™ Implant
to Regenerate Knee Cartilage
MINNEAPOLIS, Minn. – Nov. 27, 2018
– Regentis Biomaterials today announced that Twin Cities-based
TRIA Orthopedics is the first in Minnesota to perform a procedure using the
GelrinC™ implant to treat
damaged articular cartilage causing knee pain. GelrinC (pronounce “gel-rin-cee”) is an investigational
device being evaluated as a treatment to help the body regrow cartilage in the knee. TRIA is the only site
in Minnesota – and just one of 17 sites nationwide – enrolling patients with knee pain caused by
damaged knee cartilage in the SAGE clinical trial.
Articular cartilage is the smooth, white tissue covering the ends of bones where they come together to
form joints. Damage to the cartilage layer can be extremely painful for patients and is generally
associated with sudden trauma. Surgical intervention is often required because of the limited capacity
for cartilage to repair itself. The current standard of care is a procedure called microfracture, which
involves making tiny holes in the bone underneath the damaged cartilage to stimulate the growth of
new cartilage. However, the cartilage is more like scar tissue than the original hyaline cartilage; as a
result, microfracture often provides only short-term relief and may require repeat surgeries.
“There are limited options for patients who continue to experience knee pain caused by damage to their
articular cartilage,” said Dr. Brad Nelson, orthopedic surgeon. “The hope is that GelrinC, which requires
only a single minimally invasive procedure, will promote repair of the cartilage and alleviate pain.”
People 18-50 years old with pain in one knee caused by damaged articular cartilage can inquire about
the study by visiting or by calling (833) 430-8686.
About GelrinC™
In the U.S., GelrinC™ from Regentis Biomaterials is an investigational device for patients with articular
cartilage damage in their knee. GelrinC’s unique mode of action allows it to be implanted as a liquid so
that it completely fills the cartilage defect in the knee, and then be cured into a gel that enables the
body’s own stem cells to settle on its surface. Six to 12 months after surgery, the GelrinC is gradually
resorbed by the body and replaced by new cartilage tissue. Preliminary clinical trials in Europe have
indicated that this regenerated tissue provides excellent improvement in pain and function. To learn
more about GelrinC, please visit
About the SAGE Clinical Trial
The SAGE study is a Food and Drug Administration (FDA) Investigational Device Exemption (IDE) clinical
study comparing GelrinC to microfracture, the current standard of care treatment for damaged knee
cartilage. The multi-center Phase III pivotal study will enroll 120 patients. All patients who meet study
requirements and agree to enter the trial are provided GelrinC as treatment.
About Regentis Biomaterials
With offices in Princeton, New Jersey, and Or Akiva, Israel, Regentis Biomaterials is a privately held
company focused on developing and commercializing proprietary hydrogels for tissue regeneration. The
technology was originally developed at the Technion-Israel Institute of Technology by Dr. Dror Seliktar.
For more information, please visit
CAUTION Investigational device. Limited by United States law to investigational use,
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For media inquiries, please contact:
Joni Ramirez Annelise Heitkamp
Merryman Communications TRIA Orthopedics
323.532.0746 952.977.3540

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